Goals

The Zebrafish Atlas Phenotype Project (ZAPP) is a community driven effort focused on standardizing zebrafish toxicology data and phenotypic outcome reporting. ZAPP’s success depends on active participation from the zebrafish research and toxicology community to ensure that ZAPP remains fit for purpose, sustainable, and effective in improving the integration and reuse of toxicological and phenotypic data.

ZAPP aims to:

1. Develop a data model and standards to report zebrafish exposure experiments and resulting phenotypes

2. Create an annotation toolkit that enables consistent data annotation following the data model and standards. This annotation toolkit will allow standards adoption without prior knowledge of ontologies or data modeling.

3. Build a web-based, community-curated phenotype atlas that serves as a visual reference for zebrafish phenotypes

2. Annotation Toolkit for Toxicophenotype

We aim to develop a community-driven toxicophenotype annotation toolkit aligned with the toxicophenotype data model to support standardized data annotation and submission to the ZAPP Atlas.

Tutorials and curation guidelines will be provided to ensure consistent annotation across contributors.

3. Phenotype Atlas Web application

We will collect images and metadata of morphological phenotypes from toxicology studies using the toxicophenotype annotation toolkit. These data will instantiate a zebrafish phenotype atlas and provide visual standards for comparing phenotype variation across laboratories.

The open source web-based phenotype atlas will support exploration and querying of exposures and phenotypes, display representative images and link to relevant external resources. FAIR API access to the data will be provided for third-party resources.